Introduction: Gifted and talented students are human assets. This study aims to compare educational barriers of this group of students compare to other students of Arak University of Medical Sciences.

Methods: This cross-sectional analytical study carried out on 180 normal and 56 talented students in Arak University of Medical Sciences in 2011. Data were collected through questionnaire including items related to barriers of education, research, individual-family relationship, psycho-spritual needs and finding career.

Results: The mean of total problem score in talented and normed student was 52.9 ±11.4 and 48.5±10.8 respectively. Results also showed that the mean score of educational, research and psycho-spritual difficulties between talented students and other student were significantly different (P<0/05).

Conclusions: Support of academic authorities in all above mentioned fields would be helpful to improve the motivation of the gifted and talented students.